molecular beacons

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Public Health Research Institute
New Jersey Medical School - Rutgers, The State University of New Jersey
Department of Molecular Genetics, Third floor - West Wing
225 Warren Street
Newark, New Jersey 07103

Fred Russell Kramer, Ph.D. Sanjay Tyagi, Ph.D. Salvatore A.E. Marras, Ph.D.
Room W-310A Room W-310E Room W-350A
Tel: 1-973-854-3370 Tel: 1-973-854-3372 Tel: 1-973-854-3373
fred.kramer@rutgers.edu tyagisa@rutgers.edu marrassa@rutgers.edu

 


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Recent Publications from our group


Schlachter S, Chan K, Marras SAE, and Parveen N (2017) Detection and differentiation of lyme spirochetes and other tick-borne pathogens from blood using real-time PCR with molecular beacons. Methods in Molecular Biology 1616: 155-170.




Catrina IE, Bayer LV, Yanez G, McLaughlin JM, Malaczek K, Bagaeva E, Marras SAE, and Bratu DP (2016) The temporally controlled expression of Drongo, the fruit fly homolog of AGFG1, is achieved in female germline cells via P-bodies and its localization requires functional Rab11. RNA Biol 13: 1117-1132.



Vargas DY, Kramer FR, Tyagi S, and Marras SAE. (2016) Multiplex real-time PCR assays that measure the abundance of extremely rare mutations associated with cancer. PLoS ONE 11, e0156546.


We describe the use of “SuperSelective” primers that enable the detection and quantitation of somatic mutations whose presence relates to cancer diagnosis, prognosis, and therapy, in real-time multiplex PCR assays that can potentially analyze rare DNA fragments present in blood samples (liquid biopsies), thereby providing information that can be used to modify therapy for individual patients, prolonging (and improving the quality of) life.

Follow this link to access this article.