molecular beacons

Licensing Program

Public Health Research Institute Properties, Inc. (PHRI) offers non-exclusive worldwide licenses for the molecular beacons technology in a variety of fields and for a variety of uses. A license under PHRI's patents includes rights to seven different patents and patent applications and further improvements to the technology.

A complete list of countries in which patent applications are filed and a complete list of countries in which patents are issued, including their issue and termination dates can be downloaded here.

Download Patents and Patent Applications

These patents can also be viewed and printed. Issued claims describe molecular beacon probes, kits, and assays. Patents that cover additional aspects of molecular beacons technology are pending. Foreign counterparts are issued or pending in Australia, Canada, China, Europe and Japan. Licensing income received by PHRI is used to support further research. Also, a license creates a collaborative relationship with the laboratory of Drs. Fred Russell Kramer, Sanjay Tyagi, and Salvatore Marras, the inventors of the technology.

For more information on the molecular beacons licensing program, please contact Dr. Fred Russell Kramer (; 1-973-854-3370.)

Products and Assays that Utilize Molecular Beacons Technology

  1. Custom molecular beacon probes
  2. Assay kits
  3. Performance of assays for a fee
  4. Performance of assays for internal quality control
  5. Assay instruments

Fields of Use for Molecular Beacons Technology

  1. Human in vitro diagnostics
    a. Testing for infectious agents
    b. Genetic testing
    c. Oncology
  2. Research
  3. GMO testing
  4. Food testing
  5. Veterinary diagnostics
  6. Hybrid seed production
  7. Agricultural infectious agents
  8. Forensics
  9. Paternity testing
  10. High-density probe arrays
  11. Industrial microbiology
  12. Blood products quality control
  13. Environmental pathogens

The fields of use are not limited to this list. New applications and fields for molecular beacons arise frequently.

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Recent Publications from our group

Vargas DY, Marras SAE, Tyagi S, and Kramer FR. (2018) Suppression of Wild-Type Amplification by Selectivity Enhancing Agents in PCR Assays That Utilize SuperSelective Primers for the Detection of Rare Somatic Mutations. The Journal of Molecular Diagnostics, 20, 415-427

Schlachter S, Chan K, Marras SAE, and Parveen N (2017) Detection and differentiation of lyme spirochetes and other tick-borne pathogens from blood using real-time PCR with molecular beacons. Methods in Molecular Biology 1616: 155-170.

Catrina IE, Bayer LV, Yanez G, McLaughlin JM, Malaczek K, Bagaeva E, Marras SAE, and Bratu DP (2016) The temporally controlled expression of Drongo, the fruit fly homolog of AGFG1, is achieved in female germline cells via P-bodies and its localization requires functional Rab11. RNA Biol 13: 1117-1132.

Vargas DY, Kramer FR, Tyagi S, and Marras SAE. (2016) Multiplex real-time PCR assays that measure the abundance of extremely rare mutations associated with cancer. PLoS ONE 11, e0156546.

We describe the use of SuperSelective primers that enable the detection and quantitation of somatic mutations whose presence relates to cancer diagnosis, prognosis, and therapy, in real-time multiplex PCR assays that can potentially analyze rare DNA fragments present in blood samples (liquid biopsies), thereby providing information that can be used to modify therapy for individual patients, prolonging (and improving the quality of) life.

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